T.U 2O59,2061,2062
LABORATORY DIAGNOSIS OF HEPATITIS B VIRUS
Hepatitis B Surface Antigen (HBsAg) is the most important serological marker for identifying infection with Hepatitis B Virus.
HBsAg is present early in acute infection, disappears with resolution of infection and persists in chronic infection.
HBsAg is present early in acute infection, disappears with resolution of infection and persists in chronic infection.
IgM anti-HBc (IgM class antibody, against Hepatitis B Core Antigen) is essential for the diagnosis of acute infection, but is also seen occasionally in very active chronic hepatitis. Anti-HBc antibodies develop and persist after all HBV infections. The loss of HBsAg and development of anti-HBc signals resolution of acute infection.
Anti-HBs also occurs post vaccination, but anti-HBc will not be present in such cases.
Chronic infection is manifested by persistent HBsAg. Markers of viral replication such as HBeAg and HBV-DNA (non-PCR method) are detectable during the early high replication phase, but are not detectable during the later quiescent low replication phase.
HBeAg is not a reliable marker of HBV replication when a precore variant is responsible for the infection. Such cases will be HBeAg negative, anti-HBe positive, but HBV-DNA (by a non-PCR method) positive.
Anti-HBs also occurs post vaccination, but anti-HBc will not be present in such cases.
Chronic infection is manifested by persistent HBsAg. Markers of viral replication such as HBeAg and HBV-DNA (non-PCR method) are detectable during the early high replication phase, but are not detectable during the later quiescent low replication phase.
HBeAg is not a reliable marker of HBV replication when a precore variant is responsible for the infection. Such cases will be HBeAg negative, anti-HBe positive, but HBV-DNA (by a non-PCR method) positive.
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