Multiple Choice Questions on Basic Immunology Concepts

I have here presented fifteen Multiple Choice Questions from the Immunology sections. These MCQs are collected via various sources and some of the MCQs i have prepared on my knowledge. I have not posted the key (right answers) and the explanation in this blog post, because i believe in active learning and i want you to find the right answers and write the right answers in the comment box below.

After few days i will post the right answers along with explanations (if needed). Let me know.

1.       Pattern recognition receptors (PRR) include:

A.      Lectin-like molecules.

B.      Lipoteichoic acid.

C.      LPS.

D.      PAMPs.

E.       Unmethylated CpG sequences.

2.       The mononuclear phagocyte system does not include:

A.      Endothelial cells.

B.      Kidney mesangial cells.

C.      Kupffer cells.

D.      Lymph node medullary macrophages.

E.       Monocytes.

3.       A polymorphonuclear neutrophil (PMN):

A.      Is a bone marrow stem cell.

B.      Is closely similar to a mast cell.

C.      Contains microbicidal cytoplasmic granules.

D.      Is not a professional phagocytic cell.

E.       Has granules which stain with eosin.

MCQ Medical Microbiology: Immunology (21-30)

21. All of the following are true with respect to IgM antibodies EXCEPT which one

A.   they are glycoprotein

B.    they fix complement

C.    they mediate allergic reaction

D.   they occur on the surface of lymphocytes

E.    they predominate in the primary response to antigen

22.  All of the following are true with respect to IgE molecules, EXCEPT which one?

A.   They are involved in mediating anti-parasitic immune responses.

B.    They are the least abundant immunoglobulin in the serum.

C.    They are the principal immunoglobulin class involved in allergic reactions.

D.   They can effect the release of histamine and other chemical mediators.

E.    They will cross the placenta and fix complement.

23.  Which of the following immunoglobulins is present normally in plasma at the highest concentration?

A.   IgA

B.    IgD

C.    IgE

D.   IgG

E.    IgM

MCQs In Immunology: Complement system (31-40)

31.   Complement component C3 is cleaved by:

A.      C3b

B.      C3bBb

C.      Factor B

D.      Factor D

E.       Factor H

32.   The membrane attack complex  in the complement pathway consists of:

A.      C3b3b,Bb

B.      C5b,6,7,8,9

C.      Colicins

D.      OH.

E.       Properdin

33.   Complement component C3b:

A.      Directly injures bacteria.

B.      Is an anaphylatoxin.

C.      Is chemotactic.

D.      Is the inactive form of C3.

E.       Opsonizes bacteria.

MCQ in Medical Microbiology, Immunology MCQs Answers

Belows are the Key of already posted MCQs in Medical Microbiology and Immunology. If you landed to the keys for the first time, first attempt the MCQs by clicking the links provided below. Write the right answers key in rough paper and check with the given key later. In this way you can improve your Immunology knowledge. Viewing the answers and just copying the given questions and provided answers and making note won’t improve your skills.

Try these questions

·         MCQ in Medical Microbiology: Immunology MCQs(1-10)

·         MCQ in Medical Microbiology: Immunology MCQs(11-20)
      MCQs in Immunology 21-30
MCQs in Immunology (Complement System) 31-40

MCQ in Medical Microbiology: Immunology MCQs (11-20)

1.       Monoclonal antibodies are produced by

A)     hybridomas.

B)      lymphocytes.

C)      myeloma cells.         

D)     plasma cells.

       

2.       Opsonization refers to                  

A)     adherence to mucosal epithelial cells.

B)      antibody mediated viral inactivation.

C)      coating of microorganisms or other particles by antibody and/or complement.

D)     parasitic lysosomal degranulation.

3.       Which type of antibody is MOST effective in activating complement?

A)     IgG1

B)      IgG2

C)      IgG3

D)     IgM

MCQ in Medical Microbiology: Immunology MCQs (1-10)

MCQ in Medical Microbiology: Immunology MCQs (1-10)

1.       Specific immunity can be acquired either naturally or artificially and involves       

A)                 All of the below.              

B)                  antibodies.

C)                  antigens.            

D)                 the classical complement pathway.        

2.       Which DOES NOT provide long term immunity?

A)     Artificially acquired active immunity               

B)      Artificially acquired passive immunity

C)      Naturally acquired active immunity

D)     None of the above

3.       An epitope is    

A)     a B-cell.       

B)      a hapten.

C)      an antibody.

D)     the antigen determinant site.           

MCQ in Microbiology: Immunology Questions and Answers with Explanation

This is the collection of some questions to check your understanding about immunology, main definitions, terms etc. At the end of this Immunology MCQ I have posted the answers also. I expect a person who have exposure to immunology must give correct answer at least for 14 questions, if you failed to do so, please revise immunology once again.

1. Naturally acquired active immunity would be most likely acquired through which of the following processes?
   a. vaccination
   b. Drinking colostrum
   c. Natural birth
   d. infection with disease causing organism followed by recovery.
   
   

MCQ in Microbiology: Immunology

1. Naturally acquired active immunity would be most likely acquired through which of the following processes?
   a. vaccination
   b. Drinking colostrum
   c. Natural birth
   d. infection with disease causing organism followed by recovery.
2. Which of the following convey the longest lasting immunity to an infectious agent?
   a. Naturally acquired passive immunity
   b. Artificially acquired passive immunity
   c. Naturally acquired active immunity
   d. All of these
   e. None of these
3. Which of the following substances will not stimulate an immune response unless they are bound to a larger molecule?
   a. Antigen
   b. Virus
   c. Hapten
   d. Miligen
   e. Antibody

MCQ Immunology: Antibodies

1. Which of the following antibody is an important host defense against encapsulated bacteria?
   a. IgG1
   b. IgG2
   c. IgG3
   d. IgG4
2. Which of the following immunoglobulin is the most abundant immunoglobulin in newborns?
   a. IgA
   b. IgM
   c. IgG
   d. IgD

Multiple Choice Questions MCQ in Microbiology: Preparation Material One

1. Which of the following is a non pathogen
   a. Yersinia Pestis b. Cryptococcus neoformans c. Anabaena spp d. Salmonella typhi
2. Prokaryotes are distinguished from eukaryotes by their
   a. Phospholipid plasma membrane b. Cytoplasm with ribosomes c. Nucleoid instead of nucleus d. Membrane bound organelles

MCQ: Immunology 3

20. Pollen would most likely evoke which type of hypersensitivity response:
a. Cytotoxic (Type II) b. Immune complex (Type III) c. Cell Mediated (Type IV)
d. Immediate type (Type I)    e. latent (Type V).
21. Which hypersensitive reactions are T cell mediated?
a. Type I     b. Type II    c. Type III    d. Type IV    e. None of these
22. Which of the following bind to mast cells and cross-link, resulting in degranulation and release of histamine?
a. IgM           b. IgA             c. IgG          d. Interleukins    e. IgE
23. Theoretically, type………… blood can be donated to all persons because it lacks…………
a. O/antigens b. AB/ antibodies c. A/ antibodies d. O/antibodies
e. A/IgE
24. Type II hypersensitivities are due to:
a. IgE         b. Activation of cytotoxic T cells             c. Pollen            d. IgM
e. Mismatched blood types in transfusion
25. production of autoantibodies may be due to:
a. Emergence of mutant clones of B cells b. Production of antibodies against sequestered (hidden) tissues     c. genetic factors d. all are possible
e. None of these
26.A positive tuberculin test is an example of
a. Type I hypersensitivity b. Delayed type hypersensitivity c. acute contact dermatitis d. Eczema e. Pollen allergic response
27. Rheumatoid arthritis is an ……….disease that affects the……….
a. Allergic/ cartilage b. Autoimmune/nerves c. Autoimmune/ joints
d. Immunodeficiency/ muscles e. Allergic/ muscles
28. Contact with poison ivy would elicit which type of hypersensitivity reaction?
a. type III b. type I c. type ii d. type iv e. type v
29. A tissue graft between two people who are not genetically identical is termed a:
a.Isograft b. Homograft c. Endograft d. Enterograft e. Allograft

MCQ: Immunology 2

11. Cell mediated immunity is carried out by………………, while Humoral immunity is mainly carried out by…………….
a. B cells/ T cells b. T cells/ B cells c. Antibodies/ antigens
d. Epitopes/ antigens e. Antibodies/ phagocytes
12. The ability of the immune system to recognize self antigens versus non- self antigens is an example of:
a. Specific immunity b. Cell- mediated immunity c. Humoral immunity d. Tolerance e. Antigenic immunity
13. Which is NOT true of memory cells?
a. are part of a secondary response b. are part of an anamnestic
c. they can survive without dividing for many months to many years
d. they produce more IgG than IgM e. are natural killer cells
14. Which of the following antibodies would most likely be found in body secrections such as tears, milk, saliva and mucus?
a. IgA b. IgM c. IgE d. IgD e. IgG
15. Which antibody is the first to be released into the blood following an infection?
a. IgD b. IgG c. IgA d. IgE e. IgM
16. Inactivation of a toxin by an antibody is termed:
a. Lysis b. Opsonization c. Neutralization d. Attenuation
e. Lyophilization
17. An antigen that overstimualtes the immune system by binding non specifically to MHC on antigen presenting cells is termed a:
a. Non specific antigen b. Super antigen c. Epitope
d. Toxic shock syndrome e. Super necrotic
18. A vaccine that activates both cell- mediated and Humoral immunity would most likely be:
a. Heat Killed b. A toxoid c. Short-lived immunity d. Live, attenuated
e. A virion
19. DNA vaccine contain………….. DNA that stimulates cells to make………….antigens.
a. Human/ RNA b. Microbial/ Carbohydrate c. Microbial/Protein
d. Human/ Protein e. Human/Lipid

 Related Posts

1.  MCQ Immunology 1
2. MCQ Immunology 3
3.  MCQ Immunology: Antibodies

MCQ: Immunology 1

1. Naturally acquired active immunity would be most likely acquired through which of the following processes?
a. Vaccination b. Drinking colostrums c. Antivenin injection
d. sub clinical infections e. Natural birth
2. Which of the following convey the longest-lasting immunity to an infectious agent?
a. Naturally acquired passive immunity b. artificially acquired passive immunity c. naturally acquired active immunity d. All of these
e. None of these
3. Which of the following substances will not stimulate an immune response unless they are bound to a larger molecule?
a. Antigen b. Hapten c. Antibody d. virus e. Milligen
4. B cells mature in the …………….. while T cells mature in the……………
a. Thymus/ bone marrow and gut-associated lymphoid tissues (GALT)
b. Spleen/ bone marrow and GALT c. Child/ adult d. Bone marrow and GALT/ Thymus e. Liver/Kidneys
5. Which of the following immune cells/ molecules are most effective at destroying intracellular pathogens?
a. TH cells b. Antibodies c. TC cells d. B cells e. Complement

6. A living microbe with reduced virulence that is used for vaccination is considered:
a. A toxoid b. Virulent c. Denatured d. Dormant e. Attenuated
7. B cells that produce and release large amount of antibody are called:
a. Memory cells b. Plasma cells c. Neutrophils d. Basophils
e. Killer cells
8. In agglutination reactions, the antigen is a ………………
in precipitin reactions, the antigen is a ……………..
a. Whole cell/ Soluble molecule b. Soluble molecule/ Whole cell
c. Bacterium/ Virus d. Protein/ Carbohydrate e. Protein/ Antibody
9. Fusion between a plasma cell and a tumor cell creates a
a. Myeloma b. Lymphoblast c. Hybridoma d. Natural killer cell
e. Lymphoma
10. Monoclonal antibodies recognize a single
a. Antigen b. Epitope c. B cell d. Bacterium e. Virus