During the lab diagnosis of Hepatitis B, we perform serological tests. In which we can detect Antigens, HBsAg, HBeAg, Anti-HBs, Anti-HBc (Antibody against Hepatitis B core antigen). You might have wondered if there is antibody in the serum against Hepatitis B core antigen, why dont we can detect Hepatitis B core Antigen (HBcAg) from the serum.
In this blog post i have collected some information so clarify about this issue.
Hepatitis B c Antigen (HBcAg) is an intracellular antigen synthesized within
infected hepatocytes. Hepatitis B core antigen (HBcAg) are expressed by
infected hepatocytes.
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| Hepatitis B Core Antigen production and Assembly source: http://depts.washington.edu |
Most of the HBcAg that is generated is
assembled into the viral core (nucleocapsid).
Free
HBcAg does not circulate in significant quantity in the blood, but it does
circulate as part of the intact hepatitis B virion.
So HBcAg is not detected on
serum tests but antibodies produced against HbcAg i.e. (anti-HBc) can be
detected in the serum throughout the
course of HBV infection
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