Course Syllabus: TU M.Sc Microbiology First year:Immunology

Immunology

Course Title: Immunology Full Marks: 100

Course No.: MB 512                                                                                   Pass Marks: 40

Nature of Course: Theory Year: I

Objectives

Upon completion of the course, students will be able to

• Understand basic immunology
• Understand current immunological techniques and assays
• Be familiar with immunopathology of viral, bacterial, parasite, autoimmune, tumor and fungal diseases.
• Be able to search, study, comprehend and apply information gathered in current immunological journals/publications

Overview of Immunology 2 hrs

Introduction to Immunology and Serology

Cells and Tissues of the Immune System; Primary & Secondary Lymph Organs

5hrs

Innate Immunity

Development and function, Non-specific Defense against the Microbial Infections, Physical and Anatomical Barriers, Cells and Secretary molecules, serum components, Phagocytosis 5 hrs

Complements

Mechanism and significance of Classical and alternative pathways of complement system 5hrs

Antigens

Types and properties; Conditions of the antigenicity 2hrs

Antibodies and immunoglobulins

Molecular structure, Classes, subclasses, types, subtypes, Genetic basis of the Diversity 10 hrs

Antigen-antibody Reactions

Principle of Antigen-Antibody reactions in vitro

Precipitation: Types, principle, procedures and applications

Agglutination: Types, principle, procedures and applications

Immunochemical methods: Antibodies Labelling Methods

Immunofluorescence assay, ELISA

Radioimmuno assay

Immunoelectrophoresis and Immuno Blotting Methods 20 hrs

Cells and Tissues of Adaptive Immunity

Types, development and function, MHC, antigen processing, presentation and receptors 5hrs

Cell Mediated Immunity

T cell development, activation, effector mechanisms; B cell activation, Antibody production, immunological tolerance, Assays used to measure CMI 15 hrs

Humoral Immune Responses

Effector Mechanisms; Cell Signaling: Intra- & Extra-cellular mediators and pathways, Cytokines; TLR 10 hrs

Immune Disorders

Hypersensitivity, Autoimmunity & Allergy; Congenital & Acquired Immunodeficiencies 8 hrs

Diagnostic Immunology

Concept of Immunopathology and Immunodiagnostic tests, their development and use in diagnosis of infectious and non-infectious diseases (Cover at least one example from each group: Bacterial, Viral, Fungal, Parasitic, Tumor and Allergy) 15hrs

Vaccines

History of vaccine and vaccination, Types of vaccines- killed organism as a vaccine, attenuated vaccine, methods of attenuation, experimental vaccines, Overview of vaccine production techniques, Quality and Efficacy, Adverse events following immunization, Recent Developments and Prospects 15 hrs

Textbooks

1. Roitt IM and Delves PJ. Roitt’s Essential Immunology, 10^th Edition, ELBS, Blackwell Scientific Publications (2001).
2. Kindt TJ, Goldsby RA, Osborne BA. Kuby Immunology, 6^th Edition, W. H. Freeman (2006).
3. Abbas AK, Lichtman AH, and Pillai S. Cellular and Molecular Immunology, 6^th Edition, Elsevier (2007).
4. Abbas AK and Lichtman AH. Basic Immunology: Functions and Disorders of the Immune System, 3^rd Edition, W B Saunders Co (2008).
   
   More Syllabus of M.Sc First Year Microbiology (Tribhuvan University)
   

   1. Syllabus of M.Sc First year Immunology (TU)
   2. Syllabus of M.Sc First year Biochemistry-Instrumentation 
   3. Syllabus of  Microbial Biotechnology and Pharmaceutical Microbiology
   4. Syllabus of Microbial Structure, Physiology and Genetics 
   5. Syllabus of Epidemiology, Research Methods and Biostatistics
   6. Syllabus of Practical Course on (MB 513+MB 514) 
   7. Syllabus of Practical Course on (MB511+MB 512)